Dr. Robin Schubert
Utilizing novel ultra-bright X-Ray radiation sources to record molecular movies of biological reactions
Protein crystallography is a well-established method to obtain structural information with atomic resolution since several decades. By now, more than 100.000 structural models were deposited in the protein data bank and are be used for structure-based drug design (SBDD). Over the last years the development of X-ray free-electron laser have revolutionized the field and opened a new era in structural biology.
The talk will give a short introduction and overview about protein crystallography and will present applications for successful drug developments based (SBDD) on this approach. In particular, it will be highlighted why the newest generation of radiation sources, the X-ray free-electron lasers, provide unique opportunities for time-resolved crystallography experiments with very high temporal and atomic special resolution. For this, the concept of pump-probe serial femtosecond crystallography and the results of first experiments will be presented.