The registration and the lectures will take place in the lecture hall of psychiatry in the von Siebold-Straße 5

Workshop AG Zimmermann: Human ventricle in a dish

Have you ever wondered if we can generate a completely human ventricle in a dish?  We can!

Engineered human myocardium (EHM) are generated by mixing stem cell-derived cardiomyocytes and fibroblasts within a collagen matrix.  This permits us to generate self-organising and self-beating ring-shaped constructs that somewhat resemble human ventricular myocardium.  One experiment that is routinely performed in our laboratory is to determine the functionality of these EHM using isometric force transducers within a thermostatically controlled organ bath setup.

In this workshop, we will perform a short contraction experiment with EHM, explore the parameters that are derived from contraction traces, the Frank-Starling mechanism and look at pharmacological responses.

Performed by Norman Liaw, PhD - Institute of Pharmacology & Toxicology

Prof. Dr. Wolfram-Hubertus Zimmermann

Professor & Director, Department of Pharmacology (W3), Heart Research Center Goettingen, Georg-August University Goettingen.

Heart Center / Center of Pharmacology and Toxicology - University Medical Center Goettingen

Prof. Dr. Wolfram-Hubertus Zimmermann

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