Workshop AG Zimmermann: Human ventricle in a dish
Have you ever wondered if we can generate a completely human ventricle in a dish? We can!
Engineered human myocardium (EHM) are generated by mixing stem cell-derived cardiomyocytes and fibroblasts within a collagen matrix. This permits us to generate self-organising and self-beating ring-shaped constructs that somewhat resemble human ventricular myocardium. One experiment that is routinely performed in our laboratory is to determine the functionality of these EHM using isometric force transducers within a thermostatically controlled organ bath setup.
In this workshop, we will perform a short contraction experiment with EHM, explore the parameters that are derived from contraction traces, the Frank-Starling mechanism and look at pharmacological responses.
Performed by Norman Liaw, PhD - Institute of Pharmacology & Toxicology
Prof. Dr. Wolfram-Hubertus Zimmermann
Professor & Director, Department of Pharmacology (W3), Heart Research Center Goettingen, Georg-August University Goettingen.